In most developed regions, the incidence of
calcific aortic stenosis is increasing, which is one of the primary causes of valvular heart diseases, and this is expected to bolster growth of the market in North America and Europe in the foreseeable future.
Also, research suggests that Lp(a) contributes to
calcific aortic valve stenosis, a disease of the valve through which blood is pumped from the heart out to the body.
Aortic stenosis (AS), a blockage of the last valve leaving the heart, can be congenital (bicuspid valve) or
calcific (a normal valve that becomes thickened, calcified, scarred and immobile), explains Thomas Bashore, MD, Duke University Medical Center.
Calciphylaxis or
calcific uremic arteriolopathy (CUA) is a term that refers to the deposition of calcium in small and medium vessels of the skin that can result in thrombosis and necrosis of the skin, subcutaneous fat, and muscle.
"One may speculate whether there are similarities with high-intensity statin therapy, because high-intensity physical activity and exercise may promote more
calcific atherosclerosis, which may be more stable than soft, non-calcified plaques, potentially leading to coronary stability and lower propensity to more morbid CVD [cardiovascular disease] events," the authors wrote.
Orbital atherectomy modifies
calcific plaque to improve PCI results.
Search for
calcific tendinitis, tear in SST and biceps tendinitis were made.
Calciphylaxis or
calcific uremic arteriolopathy (CUA) is a rare and severe disorder characterized by systemic medial calcification of arteries and arterioles that leads to skin and soft tissues ischemic necrosis with the development of ulcers (1).
Coronary angiography (CAG) was performed in another hospital in March 2017, which showed diffuse
calcific stenosis (about 90%) in the proximal and mid-left anterior descending (LAD) artery, 70% stenosis in the ostial obtuse marginal branch, and no apparent stenosis in the right coronary artery.
A transesophageal echocardiogram showed a bicuspid aortic valve with thickened,
calcific leaflets and severe regurgitation and a mobile vegetation attached to the mitral valve cordae with subvalvular calcifications.
Coronary artery disease (
calcific plaque of blood vessel supplying the heart) cannot be assessed with CMR (angiography is the goal standard).