histone

SRC1 has an HAT domain at its carbossi-terminal region and is primarily specific for histones H3 and H4 [30], thus being involved in both chromatin remodelling and the process of recruitment/stabilization of general transcription factors [26].

To determine whether the antipsychotic drugs affected histone modification at promoter IV of the BDNF gene, ChIP assays were performed to evaluate the levels of acetylated histones H3 and MeCP2 binding in BDNF promoter IV.

"One of the factors that influences chromatin structure is proteins called histones."

HDACs are enzymes that catalyze the deacetylation of lysine remnants located at the A/-terminal of several protein substrates, such as nucleosomal histones. Histone acetylation has an important role in gene expression.

Chidamide induces chromatin remodelling by inhibiting specific subtypes of HDACs which leads to increased acetylation of histones, modifying gene expression in multiple signal transduction pathways.

Enzyme-mediated acetylations and methylations occurring on histones do not constitute the only possible PTMs taking place on histones.

Drugs that alter histones have a long history of use in psychiatry and neurology, and increasingly in cancer But current drugs tha modify histones are often times non-specific; they work across the entire genome.

Acetylation and deacetylation of histones are controlled by histone acetyltransferases (HAT) and histone deacetylases (HDACs), respectively.

The adding or removing of histone marks is carried out by a group of enzymes named (1) "writers," responsible for adding ("writing") different epigenetic marks such as HAT (histone acetyltransferase), which adds acetyl groups to histone tails, (2) "erasers," responsible for the removal of epigenetic marks of the histone, such as histone deacetylases (HDACs) or histone demethylases (HDMs), and (3) "readers," whose function is to recognize the different epigenetic marks added in the histones.

Phylogenetic analysis of the core histones H2A, H2B, H3, and H4.