luteal

The presentations will focus on recently completed studies designed to determine drug concentration and release characteristics for DARE-HRT1 and DARE-FRT1, novel intravaginal ring drug delivery product candidates containing bio-identical hormones being developed for the treatment of menopause-related vasomotor symptoms and luteal phase pregnancy maintenance, respectively.

Other important explanation for decreased PR following resynchronization protocol is that 15-26% animals don't have functional luteal tissue leading to suboptimal P4 in circulation (Silva et al., 2009; Sterry et al., 2006; Fricke et al., 2003).

This may be mainly due to the normal hormonal disturbances that occur during the late luteal phase of the menstrual cycle.

Therefore, a progesterone supplement is administered during the luteal phase to achieve optimal endometrial receptivity (4).

Another interesting report by Clementi and coworkers [54] also suggests that the luteotropic effect of the decidual tissue in rats is mediated through the secretion of pituitary PRL, which in turn stimulates P4 biosynthesis by increasing luteal 3[beta]-HSD activity, and inhibits P4 catabolism by diminishing luteal 20[alpha]-HSD activity.

The flexibility and MDS tests were also performed during the ovulation (14th day of the MC) and luteal (26th - 28th days of the MC) phases.

In many women who have a primary mood or anxiety disorder, the late luteal phase is a vulnerable time.

Whilst the mechanism responsible for this effect is likely to be at least partially related to energy supply it is also considered to involve the inhibition of prostaglandin synthesis by fat-derived hnoleic acid [8], Moreover, micronutrients are also considered to contribute to luteal function, e.g., Kawashima et al [9] reported that [beta]-carotene supply supports the postpartum reestablishment of luteal activity in dairy cows, and Arellano-Rodriguez et al [10] showed that [beta]-carotene enhances ovarian function and P4 synthesis in goats.

3, 4 Oestrogen and progesterone receptors both increase endometrial glands and stroma during follicular and early luteal phases of a normal menstrual cycle.

In addition, progesterone level in early luteal period has essential role in maintaining pregnancy.

We present here a case of OHSS resulting from luteal phase use of hCG and highlight the danger of pursuing such protocols in the circumstances of a patient at high risk of OHSS.