nucleolus

A large, round and strongly basophilic nucleolus was centrally located in the nucleus with six or seven circular nucleoli situated peripherally.

It was noticed that NOR dots could be easily visualised within the nucleoli in most of the cases.

These cells sized from small to medium, the nuclei were pale, enlarged and irregular, including a thin karyotheca, inconspicuous nucleoli, a partly visible nucleoli, and interstitial fibrous tissue hyperplasia.

(7,8,20,29,33) The initial series (8) of 4 high-grade kidney tumors in a family with HLRCC demonstrated areas of papillary architecture, abundant cytoplasm, and large nuclei with inclusion-like eosinophilic nucleoli. One tumor had admixed tubulopapillary architecture (similar to that shown in Figure 2, E), and another had admixed solid, cystic, and sarcomatoid areas.

Some authors proposed to count nucleoli rather than nuclei because the smaller diameter of nucleoli may reduce the risk of cell double-counting [31].

The Surepath and cell block preparations were hypercellular including macrophages, groups of normal salivary gland acinar cells, many dissociated and clustered uniform columnar to polygonal cells with basophilic cytoplasm, round to oval bland nuclei with fine chromatin, and inconspicuous nucleoli. Some cells with plasmacytoid appearances were present.

The cells had centrally located nuclei, inconspicuous nucleoli, and clear-to-eosinophilic cytoplasm with sharply defined cell borders (Figure 4).

Most nucleoli were prominent, often peripherally located adjacent to the nuclear membrane (centroblasts), with few large vesicular nucleoli, solitary and centrally located (immunoblasts).

Their results suggested that the N-terminal domain is indispensable for NbFib2 to target the nucleolus and cajal body, p2 binds to all three regions of NbFib2, and they target to the nucleus but fail to target the nucleoli and cajal bodies.

The nuclei were equipped with vesicular chromatin or prominent nucleoli. The mitotic index was brisk (>20 per HPF).