oncogene


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on·co·gene

 (ŏn′kə-jēn, ŏng′-)
n.
1. Any of various mutated genes that cause the transformation of normal cells into cancerous cells.
2. Any of various viral genes that transform host cells into cancerous cells.

[Greek onkos, mass, tumor; see oncology + gene.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

oncogene

(ˈɒŋkəʊˌdʒiːn)
n
(Genetics) any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
[C20 from Gk onkos mass, tumour + gene]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

on•co•gene

(ˈɒŋ kəˌdʒin)

n.
any gene that is a causative factor in the initiation of cancerous growth.
[1965–70]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.

on·co·gene

(ŏn′kə-jēn)
A gene containing a mutation in its DNA that causes normal cells to turn into cancerous ones. See Note at cancer.
The American Heritage® Student Science Dictionary, Second Edition. Copyright © 2014 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oncogene - a gene that disposes normal cells to change into cancerous tumor cellsoncogene - a gene that disposes normal cells to change into cancerous tumor cells
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive ?
The sophisticated oncogene laboratory, which is part of the ambitious Yacoub Behbehani Laboratory Building and Bone Marrow Transplantation Center, is expected to make a great difference in discovering and treating advanced and complicated types of cancer, ministry spokesman Dr.
Guilty as charged: B-RAF is a human oncogene. Cancer Cell 2004;6(4):313-9.
Overexpression of FTH1P3 promoted proliferation and colony formation in OSCC cells and the upregulation of FZD5 (frizzled class receptor 5), target of miR-224-5p and an oncogene involved in activation of Wnt/[beta]-catenin signaling.
In these cells, while stem cell potential is maintained, the oncogenic protein responsible for disease is lost ("oncogene suppression") [33, 34].
The pace of progress in battling cancers has steadily accelerated, and a relatively new tool--the oncogene panel--is beginning to prove its value.
TEHRAN (FNA)- In a study involving the fruit fly equivalent of an oncogene implicated in many human leukemias, a research team has gained insight into how developing cells normally switch to a restricted, or specialized, state and how that process might go wrong in cancer.
About 10% of lung cancer patients have mutations in the EGFR oncogene. For those patients in particular, this finding could have significant impact in developing a personalized, targeted therapy.
66 MICRORNA-29 NEGATIVELY REGULATES EXPRESSION OF ONCOGENE TET2
* Self sufficiency of growth signals: Tumors have capacity to proliferate without external stimuli, as a consequence of oncogene activation.
The key features of developing gastric cancer are hyperproliferation and oncogene expression of gastric epithelial cells.