virion

Using real-time uncoating measurements and high-resolution structures, a research team comprised of docent Varpu Marjomaki's group (Nanoscience Center at the University of Jyvaskyla) and professor Sarah Butcher's group (University of Helsinki) found that the common molecule in serum and interstitial fluids, albumin, and an ion composition that is typically developed in cellular vesicles, trigger expansion of the virion.

Virus particles were detected in lesion samples as either virion aggregates (arrows) (A) or individual virions (B) with a typical brick shape.

Bacteriophages are typically stored as a free virion; the sensitivity to storage conditions and storage media, however, vary from phage to phage.

- UK-based Virion Biotherapeutics has appointed Edwin Moses, PhD, former CEO of Ablynx, as chairman of its board of directors, the company said.

Virion Therapeutics LLC, developers of a checkpoint inhibitor powered vaccines for treatment of cancers and chronic viral infections, announced yesterday that it has added new members to its inaugural board of directors and Scientific Advisory Board.

(2013) demonstrated that a defective genotype was responsible for increased pathogenicity of a Spodoptera frugiperda nucleopolyhedrovirus (SfMNPV) isolate by modulating the concentration of a per os infection factor in the occlusion derived virion envelope.

CHIKV caused widespread outbreaks of debilitating human disease in the past few years and more than 1.9 million people have been infected.2,3 CHIKV invasion of susceptible cells is mediated by two viral glycoproteins (E1 and E2) which carry the main antigenic determinants and form an icosahedral shell at the virion surface.1 The severity of CHIKV disease rigorously effect the quality of life of infected individuals for weeks, months or even years.4

"Our study provides a detailed analysis of the changes in the lipid composition in HCV-infected cells that revealed dependency on FA [fatty acid] elongation and desaturation for effective viral replication and virion production," they reported.

Similarly to PVX TGBp1, TGBp1 of AltMV is capable of interacting with one end of the virion thus activating RNA translation in vitro [3, 38].

These G2129C and A2131Y changes could be important for the intracellular retention of the HBV virion. Supporting evidence for this hypothesis comes from the observations of other workers that concomitant changes of Glu77Gln with Pro79Gln, Ala80Pro, and Ser181Pro in the core protein appear to promote nuclear retention of HBcAg [24] and that Glu77Ala in silico destabilises the core residue-surface antigen interface which is essential for the secretion of virions after assembly [26].

"This approach and the ability to say 'that virion infected that cell' will help bring clarity to the field," said principal investigator Thomas Hope.