acarbose


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Related to acarbose: metformin, Glucobay, Miglitol

ac·ar·bose

 (ăk′är-bōs′)
n.
A drug, C25H43NO18, that reduces blood glucose levels by inhibiting the breakdown of complex carbohydrates in the intestine and is used to treat type 2 diabetes.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

acarbose

(eɪˈkɑːbəʊs)
n
a type of diabetes medicine taken orally to slow and reduce the supply of glucose to the blood.
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
Translations

acarbose

n acarbosa
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
IC50 values (as seen in Table 1) found for acarbose which is a phenolic compound and has a positive effect were found as: Serotonin hydrochloride (0.92 uM, r2: 0.9730) < 2,4,6-Trihydroxybenzaldehyde (1.84 uM, r2: 0.9823) < 3,4-Dihydroxy-5-methoxybenzoic acid (9.63 uM, r2: 0.9773) < Acarbose (10 uM).
KEYWORDS: Elderly diabetics, Insulin Glargine, Acarbose.
The intestinal alpha-glucosidase inhibitor acarbose (Glucobay; Bayer, Leverkusen, Germany) hampers the digestion of carbohydrates, lowers postprandial hyperglycemia and, secondarily, hyperinsulinemia, whereas the risk of hypoglycemia is low.
The reference standard acarbose (100 ug/ml) showed [alpha]-amylase inhibition (68.91 +- 3.09% with IC50 value of 52.99 +- 4.88 ug/ml).
Meanwhile, the partnerships Uni-Bio Science have formed with CR Zizhu (on the distribution of GeneSoftA(r) in China) and Beijing Baiao Pharmaceutical (on the development of Acarbose under the multi-drug co-development agreement signed with Beijing Sun-Novo) have borne fruit.
Both groups received an equal amount of the drug acarbose to help control blood glucose.
In laboratory studies, the researchers found that small concentrations of acarbose, a drug used to treat diabetes, significantly disrupted the activity of a group of proteins involved in the Starch Utilization System (Sus).
The medication market has different pharmaceutical products of [alpha]-glucosidase inhibitors, such as acarbose that inhibits [alpha]-amylase and [alpha]-glucosidase enzymes (7), miglitol and voglibose that inhibit [alpha]-glucosidase only (8-10).
As a classical [alpha]-glucosidase inhibitor, acarbose lowers postprandial blood glucose levels by delaying glucose absorption, as it inhibits the enzyme that cleaves oligosaccharides into mono- and disaccharides in the intestinal lumen [29].
Recently, a vast number of research studies have been carried out to find potential natural antidiabetic agents since currently used drugs such as acarbose result in noticeable gastrointestinal side effects and toxicity [7, 8].
The currently available [alpha]-glucosidase inhibitors include acarbose (AB), voglibose (VB), and miglitol (MT).
Sample treatments include a-glucosidase inhibitors (AGIs; acarbose, miglitol and voglibose) to reduce the absorption of carbohydrates in the intestine and control postprandial hyperglycemia.