Abide has developed a world class platform to discover potent and selective serine hydrolase inhibitors, which are one of the largest and most diverse classes of enzymes found in nature, which include lipases, esterases, thioesterases,
amidases, peptidases and proteasesi.
Construction, characterization, and use of small-insert gene banks of DNA isolated from soil and enrichment cultures for the recovery of novel
amidases. Environmental Microbiology, 6: 948-958.
These enzymes include dehydrogenase, glucosidases, urease,
amidases, phosphatases, arylsulphatase, cellulases, and phenol oxidases.
All endolysins are hydrolases, except for transglycolases;
amidases and muramidases are the most represented classes [88].
The pro-NP was found to be stable in all investigated GI fluids with half-lives more than 20 hours which confirm that this prodrug will pass intact through GIT; when reaching the systemic circulation, a reasonable degradation will take place by nonspecific esterases and
amidases in the liver to liberate the parent drug NP.
perfringens using a variety of tools, such as
amidases, peptidases, and lysozymes.(12) Peptidases break down proteins,
amidases break amide bonds, and lysozymes break down peptidoglycans found in cell walls of bacteria.
The grant facilitates the development of new
amidases, which are important biocatalysts for the synthesis of anticancer and antiviral drug candidates, with many chiral applications, as well.