calpain


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Related to calpain: cathepsin, calpastatin

cal·pain

 (kăl′pān′)
n.
A proteolytic enzyme regulated by the concentration of calcium ions.
[Probably cal(cium) + p(rote)a(se) + -in.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

calpain

(ˈkælpeɪn)
n
any of various enzymes in mammals and other organisms that are involved in the proteolysis of endogenous proteins and are regulated by the concentration of calcium ions
[C20: from cal(modulin) + (pa)pain]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
It reveals calpain could be a target for new drugs.
University of Bristol: Scientists reveal how a faulty gene leads to kidney disease
Immature rats were compared with adolescent and mature rats for GABA-A alpha 1 level and calpain activity.
Evaluation of Behavior, Learning, Memory Along with Apoptosis, Neuronal Damage, and GABA-A Alpha-1 Receptor Level After Status Epilepticus in Immature and Mature Rats/Immatur ve Matur Sicanlarda Status Epileptikus Sonrasi Apoptoz, Noronal Hasar, GABA-A Alfa-1 Reseptor Miktari ile Davranis, Ogrenme ve Hafizanin Degerlendirilmesi
Calpain and cathepsin activities in postmortem fish and meat muscles.
Investigation on Autolytic Processes and Microstructural Changes in Red Deer Meat
- South San Francisco, California-based anti-fibrotic therapies specialist Blade Therapeuticshas initiated a Phase 1 clinical trial for its lead compound, BLD-2660, a selective small molecule dimeric calpain inhibitor, the company said.
Blade Therapeutics Commences Phase 1 Study of Calpain Inhibitor for Fibrosis
By generating potent inhibitors to Calpain, Phelix is able to block the generation of myofibroblasts, the critical cell type in fibrosis.
Phelix Therapeutics, LLC Awarded Phase I SBIR Grant from NIH to Develop Calpain Therapeutics for Idiopathic Pulmonary Fibrosis
Polymorphism of calpastatin, calpain and myostatin genes in native Dalagh sheep in Iran.
Determining Genetic Variation of Calpastatin Gene with MspI and NcoI Enzymes by Using PCR-RFLP Method in/Kivircik Lambs/Kivircik Kuzularda PCR-RFLP Metodu Kullanilarak Calpastatin Geninin MspI ve NcoI Enzimleri ile Genetik Cesitliliginin Belirlenmesi
Eklund, "Bcr-abl regulates Stat 5 through Shp2, the interferon consensus sequence binding protein (Icsbp/Irf8), growth arrest specific 2 (Gas2) and calpain," Oncotarget, vol.
SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction
Greer, "Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis," The Journal of Biological Chemistry, vol.
Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics Pathophysiology, and Potential Therapies
Long-lasting Ca2+ elevations activate calpain proteases, which further degrade proteins that participate in Ca2+ homeostasis and thereby aggravate myoplasmic Ca2+ overload.
A Rare Case of Sunitinib-Induced Rhabdomyolysis in Renal Cell Carcinoma
Ishiguro, "[Ca.sup.2+]-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75," Archives of Biochemistry and Biophysics, vol.
Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases
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