Compared to the depsidone, psoromic acid, and to olivetoric acid ([IC.sub.50] = 221.8 [micro]M and 266.3 [micro]M for PRCC cells, 157.0 [micro]M and 37.07 [micro]M for U87MG cells), which can be considered as the alkyl
depside form of physodic acid, this latter alkyl depsidone ([IC.sub.50] = 1544.7 [micro]M for PRCC cells, 908.7 [micro]M for U87 cells) had six-fold less cytotoxicity on these cell lines (PRCC and U87MG cells) than these two related compounds, and also had the best antioxidant activity.
Study of their reactivity with the radicals resulting from alcohols:
depside formation University of Limoges France (2003).
Several potent antioxidant compounds have been isolated from Jabuticaba fruit, including jaboticabin, a
depside unique to Jabuticaba.
3.1.1.20), commonly known as "Tannase", hydrolyses the ester and
depside bonds in hydrolysable tannins.
In contrast, the new chemical variety (chemotype e) found here, contains secondary substances of chemotype a (placodiolic acid) and chemotype b (with the
depside atranorin), although, some xanthones as thiophaninic acid may be present in minor or trace concentrations and chloroatranorin is absent.
Fungal
depside, guisinol, from a marine derived strain of Emericella unguis.
For example, some
depside and depsidone compounds are shown to present anti-inflammatory activity against microsomial prostaglandin E2 synthase-1 (mPGES-1) (Bauer et al.