globin

Deletion of all four [alpha] - globin genes (homozygous [alpha]0 thalassaemia (--/--) is not compatible with life and results in afatal condition called Haemoglobin Bart's Hydrops Foetalis.

Both diseases involve mutations in the gene for beta globin protein.

Xmn1 restriction site was present at 158 bp upstream of the Gamma globin gene on chromosome 11 of positive patients (GenBank KY927385).

Human globin mRNAs are highly stable mRNAs and have been known to have half-lives that range from 10 hr to 48 hr, which is a useful attribute for mRNA therapy (15,16).

The N-terminal amino acid sequences of globin chains were obtained by the process of Edman degradation in an automated protein sequencer using an online Phenylthiohydantoin (PTH) analyzer.

In conclusion, new variants in beta globin gene are identified in the Palestinina Refugees living in Lebanon that may be correlated with reduced beta globin transcription, and phenotypic [beta]-thalassemia seen among the participants of this study.

The word thalassemia is derived from the Greek word thalassa which means "sea", and Latin word - emia (from Greek haema) meaning "blood".1 Thalassemia syndromes are a group of disorders resulting from inherited mutations which lead to decrease synthesis of either [alpha] or [beta] globin chains.

We reported to the ordering physician that beta thalassemia trait was likely, and could be confirmed by beta globin mutation analysis.

It is estimated that there are 200 million carriers of beta thalassemia gene all over the world, nine million are estimated in Pakistan.2,3 Thalassemias are genetic disorders characterized by reduced synthesis of either beta ([beta]) or alpha ([alpha]) globin chains of hemoglobin.

Globin gene transcription switches from embryonic to fetal to adult forms in humans and embryonic to adult in chickens during development.