sickled


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Related to sickled: sickle cell, sicklied
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sickle

sick·le

 (sĭk′əl)
n.
1. An implement having a crescent-shaped blade attached to a short handle, used for cutting grain or tall grass.
2. The cutting mechanism of a reaper or mower.
v. sick·led, sick·ling, sick·les
v.tr.
1. To cut with a sickle.
2. To deform (a red blood cell) into an abnormal crescent shape.
v.intr.
To assume an abnormal crescent shape. Used of red blood cells.
adj.
Shaped like the blade of a sickle; crescent-shaped: a sickle moon.

[Middle English sikel, from Old English sicol, from Vulgar Latin sicila, from Latin sēcula; see sek- in Indo-European roots.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Painful episodes can occur when sickled red blood cells, which are stiff and inflexible, get stuck in small blood vessels.
Some suppress the symptoms of the disease; some produce a positive effect on the sickled red blood cells.
A sickled hemoglobin cell, is "c" shaped, may become stuck inside blood vessels, blocking blood flow and causing damage to the body's normal cells and tissues.
The healthy cells will proliferate, and eventually, he says, they will outnumber the sickled ones.
Sickled red blood cells with irregular shape and propensity to adhere to blood vessels tend to clog blood vessels and lead to congestive splenomegaly and splenic infarcts [26, 27].
This obstruction of blood vessels by "sickled" red blood cells leads to reduced blood flow to organs, including the bone marrow, not only causing severe pain, but also cumulative tissue damage and, ultimately, loss of vital organ function and significantly reduced lifespan.
The distortion of the red cell membrane, however, may become permanent and the red cell 'irreversibly sickled'.
[5] These permanently sickled RBCs cells fail to pass through narrow capillaries, leading to vessel occlusion and ischemia.
The new blood cells survive longer than sickled cells, which could also improve treatment outcomes.
A total of 112 sickled pregnant women were identified during the study period.
These proposed mechanisms include glomerular and tubular ischaemia, iron overload and subsequent deposition in the kidneys, continued intracapillary fragmentation and phagocytosis of sickled red cells, immune complex formations, FSGS associated with glomerular hyperfiltration, and/or intrinsic glomerular capillary injury [10].