Binding of AVP to AVPR2 activates Gs/adenylate cyclase and leads to a series of intracellular events resulting in
exocytic insertion of the water channel aquaporin-2 (AQP2) from intracellular storage compartments into the luminal membrane.
Yang et al., "Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around
exocytic granules," Nature Communications, vol.
Among their effects related to the immune response, statins can alter the morphology and motility of leukocytes, endo- and
exocytic vesicle transport, phagocytosis and lysis of microorganisms, antigen processing and presentation, lymphocyte activation and proliferation, and secretion of multiple chemokines and cytokines (Lee et al., 2008).
Therefore, SNAP-25 deficiency may release VGCC activity from SNAP25-mediated inhibition, thus resulting in exaggerated calcium influx and triggering
exocytic release of glutamate.
Tamblyn et al., "The Epstein-Barr virusencoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the
exocytic and endocytic pathways," Journal of Virology, vol.
Indeed, the previous work has shown that the
exocytic sites of insulin-stimulated GLUT4 vesicle exocytosis are spatially clustered on the plasma membrane, which are disrupted and become randomized after Sec8 knockdown [101].
Van Zyl, "Overexpression of native Saccharomyces cerevisiae
exocytic SNARE genes increased heterologous cellulase secretion," Applied Microbiology and Biotechnology, vol.
Resulting from
exocytic budding, these vesicles consist of cytoplasmic components and phospholipids.