kir

Compared to fresh cells, cultured cells had lower expression of inhibitory KIRs and higher expression of activating KIRs and did not require prior IL-2 exposure for in vitro cytotoxicity.

These inhibitory killer cell immunoglobulin-like receptors (KIR) permit NK cells to recognize "self' and provide inhibitory signals to preclude killing of the target cell [2].

Pilot studies pointed at donor NK cell analysis of inhibitory KIR specific for HLA-I alleles lacking in patient cells.

Since the inhibitory receptors (killer-cell immunoglobulin-like receptors: KIRs) on NK cells were molecularly cloned (Wagtmann et al., 1995), analysis of KIR expression has contributed to determining the mechanism of NK cytolytic activity (Vivier and Daeron, 1997).

Here, we demonstrate the enhancement of the KIRs expression in vitro by Juzen-taiho-to.

However, the effect of Juzen-taiho-to alone or with cytokines on the expression of KIRs:CD158a/b, which is involved in NK cell function, has not been studied.

The effects of each KIR locus, HLA ligand, and HLA-KIR combination were examined individually by Kaplan-Meier (KM) analysis.

Association of the Onset Age with KIR Polymorphisms (Table 2).

To explore whether HLA ligands for KIR could influence the onset age of HBVrelated HCC, we grouped HLA alleles according to KIR ligand as Bw4, Bw4T, Bw4I, HLA-C1, and HLA-C2.